News
Mission statement
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Review on how the microbiome influences antibiotic susceptibility of cystic fibrosis pathogens
Article on Pseudomonas evolution in the presence of a synthetic lung microbiome
September 6, 2019
In vitro evolution of Pseudomonas aeruginosa AA2 biofilms in the presence of cystic fibrosis lung microbiome members - collaboration with Prof. Ajai Dandekar (University of Washington)
Article on role of small RNA in carbon source utilization
August 29, 2019
Small RNA NcS27 co-regulates utilization of carbon sources in Burkholderia cenocepacia J2315.
Review on the lung microbiome and antibiotics
July 8, 2019
Influence of the lung microbiome on antibiotic susceptibility of cystic fibrosis pathogens.
Article on the development of resistance to a quorum sensing inhibitor
March 27, 2019
Various Evolutionary Trajectories Lead to Loss of the Tobramycin-Potentiating Activity of the Quorum-Sensing Inhibitor Baicalin Hydrate in Burkholderia cenocepacia Biofilms
Article on using in vivo-like models for testing of new antimicrobials
February 8, 2019
The Antimicrobial Peptide lin-SB056-1 and Its Dendrimeric Derivative Prevent Pseudomonas aeruginosa Biofilm Formation in Physiologically Relevant Models of Chronic Infections - collaboration with Prof. Giovanna Batoni (University of Pisa)
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Article on vapor nanobubbles to treat bacterial biofilms
October 30, 2018
Laser-induced vapour nanobubbles improve drug diffusion and efficiency in bacterial biofilms.
1st poster prize for Lucia Grassi
September 2-4, 2018
Using in vivo-like model systems to study the efficacy of antimicrobial peptides against biofilms (collaborative work with Prof. Giovanna Batoni, University of Pisa) - presented at the IMAP 2018, Edinburgh, UK
Article on antibiotics and multispecies biofilms
September 1, 2018
Decreased susceptibility of Streptococcus anginosus to vancomycin in a multispecies biofilm is due to increased thickness of the cell wall.
The Laboratory of Pharmaceutical Microbiology (LPM) of Ghent University aims to carry out basic and applied research in the field of sociomicrobiology, i.e. research on the group behaviour of micro-organisms. More specifically, research is centered around biofilm formation by various micro-organisms grown as single cultures or multispecies communities, the evaluation of novel strategies to prevent biofilm formation and/or eradicate existing biofilms, and the molecular basis of tolerance and resistance in biofilms. The LPM also has an interest in host-microbe interactions and explores host- and microbiota directed approaches to treat bacterial infections and detrimental processes in the host due to the infection (e.g., inflammation).
Featured
Missed us at a conference?
Have a look at these past talks/abstracts
Interview with Prof. Tom Coenye for the honorary doctorate of Prof. John LiPuma
 Epigenetic control of social behavioDNA Methylation Epigenetically Regulates Gene Expression in Burkholderia cenocepacia and Controls Biofilm Formation, Cell Aggregation, and Motility July 23, 2020 | ||||||||||
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 Small RNAs in Burkholderia metabolism.Low iron-induced small RNA BrrF regulates central metabolism and oxidative stress responses in Burkholderia cenocepacia July 23, 2020 |  Congratulations Dr. Wille!PhD thesis on biofilm dispersal - March 31, 2020. |  treatment of multispecies biofilmsAntibiotic susceptibility of cystic fibrosis lung microbiome members in a multispecies biofilm – June 13, 2020. |  Grant awarded to Tom Coenyeo Concerted Research Action grant on identification of adaptive mechanisms leading to reduced antibiotic susceptibility in bacterial biofilms using experimental evolution and machine learning approaches – October 2019 |  Small RNAs in Burkholderia metabolismSmall RNA NcS27 Co-Regulates Utilization of Carbon Sources in Burkholderia cenocepacia J2315 – October 1, 2019. |  ESCMID research grant for A CrabbéStudy on the influence of host metabolites on antibiotic activity – April 1, 2020 |  Metabolism and antibiotic toleranceReview article on how metabolic adaptation in microbial biofilms influences tolerance to antibiotics - June 6, 2019. |  Best paper award for Rosalie!Rosalie Swimberghe received the prestigious Wladimir Adlivankine Research Prize from the European Society for Endodontology for her work on endodontic biofilm models - September 12, 2019 |  Congratulations Dr. Eline Teirlinck!PhD thesis on using vapor nanobubbles to treat biofilms (Laboratory for General Biochemistry and Physical Pharmacy (Prof. K Braeckmans) and Laboratory of Pharmaceutical Microbiology (Prof. T Coenye)). June 24, 2019. Click on the link below to discover her work. |  Lung cells influence antibioticsPublication on how 3-D lung epithelial cells enhance the activity of aminoglycoside antibiotics - April 29, 2019 |  Congratulations Dr. Vandeplassche!PhD thesis on antibiotic efficacy in multispecies biofilms - November 21, 2018. Discover Eva Vandeplassche's work below. |